Nucleus pulposus cell network modelling in the intervertebral disc

• Published in: NPJ systems biology and applications Vol. 11; no. 1; pp. 13 - 17
• Main Authors: Tseranidou, Sofia, Segarra-Queralt, Maria, Chemorion, Francis Kiptengwer, Le Maitre, Christine Lyn, Piñero, Janet, Noailly, Jérôme
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 31.01.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/553/2393; 631/553/2711; Bioinformatics; Biology; Biomedical and Life Sciences; Cartilage; Collagen; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Cytokines; Degeneration; Degenerative disc disease; Experimental research; Extracellular matrix; Extracellular Matrix - metabolism; Humans; Interleukin 1; Interleukin 1 receptor antagonist; Interleukin 1 receptors; Intervertebral Disc - cytology; Intervertebral Disc - metabolism; Intervertebral Disc Degeneration - metabolism; Intervertebral Disc Degeneration - pathology; Intervertebral discs; Knowledge; Life Sciences; Models, Biological; Nucleus pulposus; Nucleus Pulposus - cytology; Nucleus Pulposus - metabolism; Ordinary differential equations; Proteins; Systems Biology; Transforming Growth Factor beta - metabolism; Transforming growth factor-b

Intervertebral disc degeneration (IDD) results from an imbalance between anabolic and catabolic processes in the extracellular matrix (ECM). Due to complex biochemical interactions, a comprehensive understanding is needed. This study presents a regulatory network model (RNM) for nucleus pulposus cel...