Exploration of the medical periodic table: towards new targets

Metallodrugs offer potential for unique mechanisms of drug action based on the choice of the metal, its oxidation state, the types and number of coordinated ligands and the coordination geometry. We discuss recent progress in identifying new target sites and elucidating the mechanisms of action of a...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 49; no. 45; pp. 5106 - 5131
Main Authors Barry, Nicolas P. E., Sadler, Peter J.
Format Journal Article
LanguageEnglish
Published England 01.01.2013
Subjects
Animals
chelating agents
Chelating Agents - chemistry
Chelating Agents - pharmacology
chemical communication
clinical trials
Clinical Trials as Topic
Drug Design
Drug Discovery - methods
drugs
enzyme inhibitors
genomics
geometry
Humans
ligands
mechanism of action
Metals - chemistry
Metals - pharmacology
Models, Molecular
Molecular Targeted Therapy
oxidation
proteomics
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Summary:Metallodrugs offer potential for unique mechanisms of drug action based on the choice of the metal, its oxidation state, the types and number of coordinated ligands and the coordination geometry. We discuss recent progress in identifying new target sites and elucidating the mechanisms of action of anti-cancer, anti-bacterial, anti-viral, anti-parasitic, anti-inflammatory, and anti-neurodegenerative agents, as well as in the design of metal-based diagnostic agents. Progress in identifying and defining target sites has been accelerated recently by advances in proteomics, genomics and metal speciation analysis. Examples of metal compounds and chelating agents (enzyme inhibitors) currently in clinical use, clinical trials or preclinical development are highlighted.
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c3cc41143e