Nanocomposite scaffold fabrication by incorporating gold nanoparticles into biodegradable polymer matrix: Synthesis, characterization, and photothermal effect

• Published in: Materials Science & Engineering C Vol. 56; pp. 305 - 310
• Main Authors: Abdelrasoul, Gaser N., Farkas, Balazs, Romano, Ilaria, Diaspro, Alberto, Beke, Szabolcs
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2015
• Subjects: Au nanoparticles; Biodegradability; Biodegradable scaffolds; Gold; Gold - chemistry; Hybrid nanocomposites; Metal Nanoparticles - chemistry; Nanocomposites - chemistry; Nanoparticles; Nanostructure; Photocuring; Polymers; Povidone - chemistry; Resins; Scaffolds; Stability; Hybrid nanocomposites; Au nanoparticles; Biodegradable scaffolds; Photocuring
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2015.06.037

Nanoparticle incorporation into scaffold materials is a valuable route to deliver various therapeutic agents, such as drug molecules or large biomolecules, proteins (e.g. DNA or RNA) into their targets. In particular, gold nanoparticles (Au NPs) with their low inherent toxicity, tunable stability and high surface area provide unique attributes facilitating new delivery strategies. A biodegradable, photocurable polymer resin, polypropylene fumarate (PPF) along with Au NPs were utilized to synthesize a hybrid nanocomposite resin, directly exploitable in stereolithography (SL) processes. To increase the particles' colloidal stability, the Au NP nanofillers were coated with polyvinyl pyrrolidone (PVP). The resulting resin was used to fabricate a new type of composite scaffold via mask projection excimer laser stereolithography. The thermal properties of the nanocomposite scaffolds were found to be sensitive to the concentration of NPs. The mechanical properties were augmented by the NPs up to 0.16μM, though further increase in the concentration led to a gradual decrease. Au NP incorporation rendered the biopolymer scaffolds photosensitive, i.e. the presence of Au NPs enhanced the optical absorption of the scaffolds as well, leading to possible localized temperature rise when irradiated with 532nm laser, known as the photothermal effect. •Gold nanoparticle incorporation into biopolymer resin was realized.•Gold incorporation into biopolymer resin is a big step in tissue engineering.•Composite scaffolds were synthesized and thoroughly characterized.•Gold nanoparticles are remarkable candidates to be utilized as “transport vehicles”.•The photothermal effect was demonstrated using a 532-nm laser.