Genes involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharide in Streptococcus mutans

We identified in Streptococcus mutans six new genes (rgpA through rgpF), whose disruption results in a loss of serotype-specific antigenicity, specified by the glucose side chains of rhamnose-glucose polysaccharide from the cell wall. Rhamnose and glucose content of the cell wall decreased drastical...

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Published inJournal of bacteriology Vol. 180; no. 21; pp. 5803 - 5807
Main Authors Yamashita, Y, Tsukioka, Y, Tomihisa, K, Nakano, Y, Koga, T
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.11.1998
SeriesNote
Subjects
Amino Acid Sequence
Animals
Bacteria
Bacteriology
Base Sequence
Cell Surfaces
Cell Wall - chemistry
Cloning, Molecular
DNA, Bacterial
Genes
Genes, Bacterial
Glucose
Microbiology
Molecular Sequence Data
Mutagenesis, Insertional
Polysaccharides, Bacterial - biosynthesis
Polysaccharides, Bacterial - chemistry
Polysaccharides, Bacterial - immunology
Rabbits
Rhamnose
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Streptococcus mutans
Streptococcus mutans - genetics
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Summary:We identified in Streptococcus mutans six new genes (rgpA through rgpF), whose disruption results in a loss of serotype-specific antigenicity, specified by the glucose side chains of rhamnose-glucose polysaccharide from the cell wall. Rhamnose and glucose content of the cell wall decreased drastically in all these disruption mutants, except that in the rgpE mutant only the glucose content decreased. RgpC and RgpD are homologous to ATP-binding cassette transporter components and may be involved in polysaccharide export, whereas RgpE may be a transferase of side chain glucose.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Corresponding author. Mailing address: Department of Preventive Dentistry, Kyushu University Faculty of Dentistry, Fukuoka 812-8582, Japan. Phone: 81-92-642-6353. Fax: 81-92-642-6354. E-mail: yoshidha@mbox.nc.kyushu-u.ac.jp.
ISSN:0021-9193
1098-5530
DOI:10.1128/jb.180.21.5803-5807.1998