A breach in the scaffold: The possible role of cytoskeleton dysfunction in the pathogenesis of major depression

Highlights ► Not only actin, microtubules can also maintain dendrite and dendritic spine function. ► We summarize the significance of posttranslational modification of cytoskeleton. ► We summarize different modes of posttranslational modification of cytoskeleton. ► Abnormality of cytoskeletal posttr...

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Bibliographic Details
Published inAgeing research reviews Vol. 12; no. 1; pp. 67 - 75
Main Authors Wong, Ginger Tsz-Hin, Chang, Raymond Chuen-Chung, Law, Andrew Chi-Kin
Format Journal Article
LanguageEnglish
Published England 01.01.2013
Subjects
Actin Cytoskeleton - genetics
Actin Cytoskeleton - physiology
Animals
Cytoskeleton - physiology
Dendrites - pathology
Dendritic Spines - pathology
Depressive Disorder, Major - genetics
Depressive Disorder, Major - physiopathology
Humans
Internal Medicine
Mental Disorders - genetics
Mental Disorders - physiopathology
Microtubules - genetics
Microtubules - physiology
Neurology
Protein Processing, Post-Translational - genetics
Protein Processing, Post-Translational - physiology
Post-translational modification
Depression
Cytoskeleton
Tubulin
Microtubule
Actin
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Summary:Highlights ► Not only actin, microtubules can also maintain dendrite and dendritic spine function. ► We summarize the significance of posttranslational modification of cytoskeleton. ► We summarize different modes of posttranslational modification of cytoskeleton. ► Abnormality of cytoskeletal posttranslational modification can occur in depression.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2012.08.004