An mRNA vaccine candidate encoding H5HA clade 2.3.4.4b protects mice from clade 2.3.2.1a virus infection

Highly pathogenic avian influenza (HPAI) H5 viruses from different clades have been circulating globally, threatening wild/domestic birds and mammals. Given frequent spillovers and high mortality among mammals, coupled with our inability to predict which clade of H5 virus has pandemic potential, cro...

Full description

Saved in:
Bibliographic Details
Published innpj vaccines Vol. 9; no. 1; pp. 189 - 5
Main Authors Chiba, Shiho, Kiso, Maki, Yamada, Shinya, Someya, Kazuhiko, Onodera, Yoshikuni, Yamaguchi, Aya, Matsunaga, Satoko, Uraki, Ryuta, Iwatsuki-Horimoto, Kiyoko, Yamayoshi, Seiya, Takeshita, Fumihiko, Kawaoka, Yoshihiro
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 14.10.2024
Nature Publishing Group
Nature Portfolio
Subjects
631/250/590/2293
692/699/255/1578
Animals
Antibodies
Antigens
Avian flu
Biomedical and Life Sciences
Biomedicine
Birds
Brief Communication
Drug dosages
Immunity (Disease)
Infections
Infectious Diseases
Laboratories
Mammals
Medical Microbiology
Mortality
mRNA vaccines
Nanoparticles
Pandemics
Penicillin
Poultry
Public Health
Vaccine
Vaccines
Variance analysis
Virology
Viruses
Online AccessGet full text

Cover

More Information
Summary:Highly pathogenic avian influenza (HPAI) H5 viruses from different clades have been circulating globally, threatening wild/domestic birds and mammals. Given frequent spillovers and high mortality among mammals, coupled with our inability to predict which clade of H5 virus has pandemic potential, cross-clade protective HPAI H5 vaccines are urgently needed. Here, we demonstrate the applicability of a lipid nanoparticle-based mRNA vaccine modality to induce cross-protective immunity against lethal HPAI virus infection.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2059-0105
2059-0105
DOI:10.1038/s41541-024-00988-9