Palladium-mediated in situ synthesis of an anticancer agent
As a novel prodrug activation strategy Pd(0) nanoparticles, entrapped within a modular polymeric support, were used in cell culture, to synthesise the anticancer agent PP-121 from two non-toxic precursors, thereby inducing cell death in the first example of in situ mediated drug synthesis.
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Published in | Chemical communications (Cambridge, England) Vol. 52; no. 99; pp. 14212 - 14214 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.01.2016
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Subjects | |
Online Access | Get full text |
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Summary: | As a novel prodrug activation strategy Pd(0) nanoparticles, entrapped within a modular polymeric support, were used in cell culture, to synthesise the anticancer agent PP-121 from two non-toxic precursors, thereby inducing cell death in the first example of in situ mediated drug synthesis. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/c6cc08666g |