Palladium-mediated in situ synthesis of an anticancer agent

As a novel prodrug activation strategy Pd(0) nanoparticles, entrapped within a modular polymeric support, were used in cell culture, to synthesise the anticancer agent PP-121 from two non-toxic precursors, thereby inducing cell death in the first example of in situ mediated drug synthesis.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 52; no. 99; pp. 14212 - 14214
Main Authors Indrigo, Eugenio, Clavadetscher, Jessica, Chankeshwara, Sunay V, Lilienkampf, Annamaria, Bradley, Mark
Format Journal Article
LanguageEnglish
Published England 01.01.2016
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Summary:As a novel prodrug activation strategy Pd(0) nanoparticles, entrapped within a modular polymeric support, were used in cell culture, to synthesise the anticancer agent PP-121 from two non-toxic precursors, thereby inducing cell death in the first example of in situ mediated drug synthesis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc08666g