Macrolides and ketolides: azithromycin, clarithromycin, telithromycin

• Published in: Infectious disease clinics of North America Vol. 18; no. 3; p. 621
• Main Author: Zuckerman, Jerry M
• Format: Journal Article
• Language: English
• Published: United States 01.09.2004
• Subjects: Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Azithromycin - pharmacology; Azithromycin - therapeutic use; Bacterial Infections - drug therapy; Clarithromycin - pharmacology; Clarithromycin - therapeutic use; Humans; Ketolides - pharmacology; Ketolides - therapeutic use; Macrolides - pharmacology; Macrolides - therapeutic use

The advanced macrolides, azithromycin and clarithromycin, and the ketolide telithromycin are structural analogues of erythromycin. They have several distinct advantages when compared with erythromycin including enhanced spectrum of activity, more favorable pharmacokinetics and pharmacodynamics, once...