Macrolides and ketolides: azithromycin, clarithromycin, telithromycin

The advanced macrolides, azithromycin and clarithromycin, and the ketolide telithromycin are structural analogues of erythromycin. They have several distinct advantages when compared with erythromycin including enhanced spectrum of activity, more favorable pharmacokinetics and pharmacodynamics, once...

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Bibliographic Details
Published inInfectious disease clinics of North America Vol. 18; no. 3; p. 621
Main Author Zuckerman, Jerry M
Format Journal Article
LanguageEnglish
Published United States 01.09.2004
Subjects
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Azithromycin - pharmacology
Azithromycin - therapeutic use
Bacterial Infections - drug therapy
Clarithromycin - pharmacology
Clarithromycin - therapeutic use
Humans
Ketolides - pharmacology
Ketolides - therapeutic use
Macrolides - pharmacology
Macrolides - therapeutic use
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Summary:The advanced macrolides, azithromycin and clarithromycin, and the ketolide telithromycin are structural analogues of erythromycin. They have several distinct advantages when compared with erythromycin including enhanced spectrum of activity, more favorable pharmacokinetics and pharmacodynamics, once daily administration, and improved tolerability. This article reviews the pharmacokinetics, antimicrobial activity, clinical use, and adverse effects of these antimicrobial agents.
ISSN:0891-5520
DOI:10.1016/j.idc.2004.04.010