Modulatory Properties of Aloe secundiflora's Methanolic Extracts on Targeted Genes in Colorectal Cancer Management

Colon tumors have a very complicated and poorly understood pathogenesis. Plant-based organic compounds might provide a novel source for cancer treatment with a sufficient novel mode of action. The objective of this study was to analyze and evaluate the efficacy of (AS) methanolic extracts on the exp...

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Published inCancers Vol. 15; no. 20; p. 5002
Main Authors Macharia, John M, Varjas, Timea, Mwangi, Ruth W, Káposztás, Zsolt, Rozmann, Nóra, Pintér, Márton, Wagara, Isabel N, Raposa, Bence L
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 16.10.2023
MDPI
Subjects
Aloe secundiflora
Apoptosis
Bcl-2 protein
Bcl-x protein
Cancer therapies
Colon cancer
Colorectal cancer
Colorectal carcinoma
Down-regulation
Fatalities
Genes
Metabolites
Metastases
Methanol
Phytochemicals
Solvents
Tumor cell lines
Tumors
Kenya
Africa
molecular mechanism
colorectal cancer
tumor microenvironment
phytotherapeutic effects
genome modulatory pathways
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Summary:Colon tumors have a very complicated and poorly understood pathogenesis. Plant-based organic compounds might provide a novel source for cancer treatment with a sufficient novel mode of action. The objective of this study was to analyze and evaluate the efficacy of (AS) methanolic extracts on the expression of , , , , and in colorectal cancer (CRC) management. Caco-2 cell lines were used in the experimental study. In the serial exhaustive extraction (SEE) method, methanol was utilized as the extraction solvent. Upon treatment of with the methanolic extracts, the expression of the genes was progressively upregulated, thus, dose-dependently increasing the rate of apoptosis. On the other hand, the expressions of , , and were variably downregulated in a dose-dependent manner. This is a unique novel study that evaluated the effects of AS methanolic extracts in vitro on CRC cell lines using different dosage concentrations. We, therefore, recommend the utilization of AS and the application of methanol as the extraction solvent of choice for maximum modulatory benefits in CRC management. In addition, we suggest research on the specific metabolites in AS involved in the modulatory pathways that suppress the development of CRC and potential metastases.
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ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15205002