Nuclear reprogramming

There is currently particular interest in the field of nuclear reprogramming, a process by which the identity of specialised cells may be changed, typically to an embryonic-like state. Reprogramming procedures provide insight into many mechanisms of fundamental cell biology and have several promisin...

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Bibliographic Details
Published inDevelopment (Cambridge) Vol. 140; no. 12; pp. 2468 - 2471
Main Authors Halley-Stott, Richard P, Pasque, Vincent, Gurdon, J B
Format Journal Article
LanguageEnglish
Published England 15.06.2013
Subjects
Animals
Cell Membrane - metabolism
Cell Transdifferentiation
Cellular Reprogramming
Embryo, Mammalian - cytology
Embryo, Mammalian - metabolism
Epigenesis, Genetic
Humans
Induced Pluripotent Stem Cells - cytology
Induced Pluripotent Stem Cells - metabolism
Meiotic Prophase I
Metaphase
Nuclear Transfer Techniques
Ovum - cytology
Ovum - metabolism
Transcription, Genetic
Nuclear transfer
Pluripotent
Reprogramming
Cell fusion
Transdifferentiation
Induced pluripotency
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Summary:There is currently particular interest in the field of nuclear reprogramming, a process by which the identity of specialised cells may be changed, typically to an embryonic-like state. Reprogramming procedures provide insight into many mechanisms of fundamental cell biology and have several promising applications, most notably in healthcare through the development of human disease models and patient-specific tissue-replacement therapies. Here, we introduce the field of nuclear reprogramming and briefly discuss six of the procedures by which reprogramming may be experimentally performed: nuclear transfer to eggs or oocytes, cell fusion, extract treatment, direct reprogramming to pluripotency and transdifferentiation.
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ISSN:0950-1991
1477-9129
DOI:10.1242/dev.092049