Decreased Methylation of the Mitochondrial D-Loop Region in Late-Onset Alzheimer's Disease

Mitochondrial impairment is a feature of neurodegeneration and many investigators have suggested that epigenetic modifications of the mitochondrial DNA (mtDNA) might be involved in late-onset Alzheimer's disease (LOAD), but evidence in humans is limited. We assessed the methylation levels of th...

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Bibliographic Details
Published inJournal of Alzheimer's disease Vol. 59; no. 2; p. 559
Main Authors Stoccoro, Andrea, Siciliano, Gabriele, Migliore, Lucia, Coppedè, Fabio
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2017
Subjects
Aged
Aged, 80 and over
Alzheimer Disease - genetics
Case-Control Studies
DNA Methylation - genetics
DNA, Mitochondrial - genetics
Female
Gene Expression Profiling
Gene Regulatory Networks
Humans
Male
Mitochondria - metabolism
Mitochondria - pathology
Peptides, Cyclic - chemistry
Peptides, Cyclic - genetics
Peptides, Cyclic - metabolism
Statistics, Nonparametric
Transcriptome
DNA methylation
Alzheimer’s disease
mtDNA
D-loop region
mitochondrial DNA
epigenetics
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Summary:Mitochondrial impairment is a feature of neurodegeneration and many investigators have suggested that epigenetic modifications of the mitochondrial DNA (mtDNA) might be involved in late-onset Alzheimer's disease (LOAD), but evidence in humans is limited. We assessed the methylation levels of the mtDNA D-loop region in blood DNA from 133 LOAD patients and 130 controls, observing a significant 25% reduction of DNA methylation levels in the first group (2.3 versus 3.1%). Overall, the present data indicate that there is a decreased methylation of the D-loop region in LOAD peripheral blood DNA, suggesting that mtDNA epimutations deserve further investigations in AD pathogenesis.
ISSN:1875-8908
DOI:10.3233/jad-170139