Toxicity of lapachol and isolapachol and their potassium salts against Biomphalaria glabrata, Schistosoma mansoni cercariae, Artemia salina and Tilapia nilotica

The toxicity of soluble derivatives (potassium salt) of lapachol and isolapachol in different stages of the life cycle of Schistosoma mansoni is evaluated. The potassium salts of isolapachol and lapachol showed significant molluscicidal activity against the adult snail (LC 90<7 ppm) and snail egg...

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Published inActa tropica Vol. 83; no. 1; pp. 43 - 47
Main Authors Lima, Nadja Maria Fernandes, dos Santos, Aldenir Feitosa, Porfı́rio, Zenaldo, Goulart, Marı́lia O.F, Sant'Ana, Antônio Euzébio G
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.07.2002
Elsevier
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Summary:The toxicity of soluble derivatives (potassium salt) of lapachol and isolapachol in different stages of the life cycle of Schistosoma mansoni is evaluated. The potassium salts of isolapachol and lapachol showed significant molluscicidal activity against the adult snail (LC 90<7 ppm) and snail egg masses (LC 90<3 ppm). Cercaricidal assays revealed strong activities for both compounds. Lethality assays against brine shrimp eggs ( Artemia salina Leach) indicated very high toxicity for the potassium salt of isolapachol (LC 90=1.54 ppm), differently from the potassium salt of lapachol that can be considered non toxic (LC 90=176.3 ppm). The same tendency is observed with piscicidal activity, for which the isolapachol salt has showed higher toxicity. The obtained selectivity ratios concerning LC 50 and LC 90 for lapachol, in relation to Tilapia nilotica lethality assay are 2.33 and 1.26, respectively. Despite the piscicidal toxicity, the use of the salt of lapachol can be recommended for field tests in Schistosomiasis, with caution.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0001-706X
1873-6254
DOI:10.1016/S0001-706X(02)00055-4