S-phenylmercapturic acid (S-PMA) levels in urine as an indicator of exposure to benzene in the Kinshasa population

• Published in: International journal of hygiene and environmental health Vol. 216; no. 4; pp. 494 - 498
• Main Author: Tuakuila, J.
• Format: Journal Article
• Language: English
• Published: München Elsevier GmbH 01.07.2013; Elsevier
• Subjects: Acetylcysteine - analogs & derivatives; Acetylcysteine - urine; Adolescent; Adult; Aged; Air. Soil. Water. Waste. Feeding; Benzene; Benzene - analysis; Biological and medical sciences; Biomonitoring; Child; Democratic Republic of the Congo; Environment. Living conditions; Environmental Monitoring; Environmental Pollutants - analysis; Environmental pollution; Female; Humans; Male; Medical sciences; Middle Aged; Miscellaneous; Public health. Hygiene; Public health. Hygiene-occupational medicine; Reference values; Rural Population; S-phenylmercapturic acid; Toxicology; Urban Population; Young Adult; Congo (Democratic republic); Africa; Democratic Republic of the Congo; Biomonitoring; Environmental pollution; Benzene; Reference values; S-phenylmercapturic acid; Human; Urine; Biological fluid; Reference value; Exposure; Indicator; Biological monitoring; Pollution; Health and environment; Acids; Environment; Environmental medicine; Population; Public health
• ISSN: 1438-4639; 1618-131X
• DOI: 10.1016/j.ijheh.2013.03.012

Data on human exposure to chemicals in Africa are scarce. A biomonitoring study was conducted in a representative sample of the population in Kinshasa (Democratic Republic of Congo) to document exposure to benzene. S-phenylmercapturic acid (S-PMA) was measured by LC–MS/MS in spot urine samples from 220 individuals (50.5% women), aged 6–70 years living in the urban area and from 50 additional subjects from the sub-rural area of Kinshasa. Data were compiled as arithmetic means, geometric means, percentile 95th and range expressed in μg/L. Overall, living in urban Kinshasa was associated with increased levels of S-PMA in urine as compared to a population living in the sub-rural area. Increased levels were also found by comparison with some date from literature. This study reveals the high benzene exposure of the Kinshasa population requiring the determination of benzene concentrations in ambient air of Kinshasa and limit values for the protection of human health.