The significance of microRNA-148/152 family as a prognostic factor in multiple human malignancies: a meta-analysis

• Published in: Oncotarget Vol. 8; no. 26; pp. 43344 - 43355
• Main Authors: Miao, Chenkui, Zhang, Jianzhong, Zhao, Kai, Liang, Chao, Xu, Aiming, Zhu, Jundong, Wang, Yuhao, Hua, Yibo, Tian, Ye, Liu, Shouyong, Zhang, Chao, Qin, Chao, Wang, Zengjun
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 27.06.2017
• Subjects: Biomarkers, Tumor; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Meta-Analysis; MicroRNAs - genetics; Multigene Family; Neoplasms, Multiple Primary - genetics; Neoplasms, Multiple Primary - mortality; Prognosis; Publication Bias; human malignancies; meta-analysis; miR-148/152 family; prognosis
• ISSN: 1949-2553; 1949-2553
• DOI: 10.18632/oncotarget.17949

Recent studies have demonstrated that microRNA-148/152 family emerges as a attractive biomarker for predicting tumor prognosis and progression. However, outcomes of different studies are controversial. Eligible Literature were searched through online databases: PubMed, EMBASE and Web of Science. A total of 24 eligible studies were ultimately enrolled in this meta-analysis. Results indicated that overexpression of miR-148/152 family was significantly correlated with enhanced overall/cause-specific survival (OS/CSS) (HR=0.63, 95% CI: 0.54-0.74). Stratified analysis indicated that high miR-148a and miR-148b expression predicted favorable OS/CSS (HR=0.76; 95% CI: 0.69-0.90) and (HR=0.49; 95% CI: 0.39-0.61), while miR-152 developed no significant impact (HR=0.40, 95% CI: 0.12-1.29). MiR-148/152 family was distinctly associated with superior OS/CSS in Asian (HR=0.53, 95% CI: 0.44-0.64), but not in Caucasian (HR=0.96, 95% CI: 0.82-1.13). Futhermore, miR-148/152 family expression also predicted longer disease/relapse/progression-free survival (DFS/RFS/PFS) (HR=0.37, 95% CI: 0.16-0.88). A significantly favorable DFS/RFS/PFS was observed in Asian (HR=0.21, 95% CI: 0.06-0.81) than that in Caucasian (HR=0.76, 95% CI: 0.31-1.87). miR-148/152 family overexpression also predicted longer DFS/RFS/PFS in tissues (HR=0.11, 95% CI: 0.01-0.98), but not in plasma/serum (HR=0.67, 95% CI: 0.38-1.18). Our meta-analysis demonstrated that overexpression of miR-148/152 predicted enhanced OS/CSS and DFS/RFS/PFS of cancer patients. MiR-148a/b family may serve as a potential prognostic factor in multiple human malignancies.