Distribution of human papillomavirus type 16 variants in human immunodeficiency virus type 1-positive and -negative women

• Published in: Journal of general virology Vol. 85; no. 5; pp. 1237 - 1241
• Main Authors: Chaturvedi, Anil K, Brinkman, Joeli A, Gaffga, Ann M, Dumestre, Jeanne, Clark, Rebecca A, Braly, Patricia S, Dunlap, Kathleen, Kissinger, Patricia J, Hagensee, Michael E
• Format: Journal Article
• Language: English
• Published: Reading Soc General Microbiol 01.05.2004; Society for General Microbiology
• Subjects: Adult; African Americans; Biological and medical sciences; Cervix Uteri - virology; Cohort Studies; Cross-Sectional Studies; Female; Fundamental and applied biological sciences. Psychology; Genetic Variation; HIV Seronegativity; HIV Seropositivity - complications; HIV-1 - immunology; Human immunodeficiency virus 1; Human papillomavirus 16; Human viral diseases; Humans; Infectious diseases; Louisiana; Medical sciences; Microbiology; Miscellaneous; Mutation; Papillomaviridae - genetics; Papillomaviridae - isolation & purification; Papillomavirus Infections - complications; Papillomavirus Infections - ethnology; Papillomavirus Infections - virology; Vagina - virology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Virology; Louisiana; USA, Louisiana, New Orleans; Human; Immunopathology; Microbiology; HIV-1 virus; Retroviridae; AIDS; Papovaviridae; Immune deficiency; Lentivirus; Virology; Infection; Papillomavirus; Virus; Human papillomavirus 16; Human papillomavirus; Viral disease; Distribution; Female; Human immunodeficiency virus; Woman
• ISSN: 0022-1317; 1465-2099
• DOI: 10.1099/vir.0.19694-0

1 Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, New Orleans, LA 70112, USA 2 Department of Microbiology, Louisiana State University Health Sciences Center, 1542 Tulane Avenue, New Orleans, LA 70112, USA 3 Department of Medicine, Louisiana State University Health Sciences Center, 1542 Tulane Avenue, New Orleans, LA 70112, USA 4 Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, 1542 Tulane Avenue, New Orleans, LA 70112, USA Correspondence Michael E. Hagensee mhagen{at}lsuhsc.edu The prevalence of human papillomavirus type 16 E6 variant lineages was characterized in a cross-sectional study of 24 human immunodeficiency virus type 1 (HIV)-positive and 33 HIV-negative women in New Orleans. The European prototype was the predominant variant in the HIV-negative women (39·4 %), while in the HIV-positive women the European 350G variant was predominant (29·1 %). In exact logistic regression models, HIV-positive women were significantly more likely to harbour any variant with a nucleotide G-350 mutation compared with HIV-negative women [58·3 % vs 21·1 %; adjusted odds ratio (AOR)=6·28, 95 % confidence interval (CI)=1·19–46·54]. Models also revealed a trend towards increased prevalence of Asian–American lineage in HIV-positive women compared with HIV-negative women (25·0 % vs 6·0 %; AOR=6·35, 95 % CI=0·77–84·97). No association was observed between any variant and cytology or CD4 cell counts or HIV-1 viral loads. These observations reflect a difference in the distribution of HPV-16 variants among HIV-positive and -negative women, indicating that HIV-positive status may lead to increased prevalence of a subset of variants.