TIM3 and CTLA4 immune checkpoint polymorphisms are associated with acute myeloid leukemia in Saudi Arabia

Immune checkpoints are receptors on the surface of T cells that function crucially in suppressing the immune response, and they are implicated in autoimmunity and cancer diseases. The present study aimed to investigate the relationship between functional single nucleotide polymorphisms (SNPs) of two...

Full description

Saved in:
Bibliographic Details
Published inHematology (Luxembourg) Vol. 29; no. 1; p. 2329024
Main Authors Alqahtani, Mashael, Aljuaimlani, Ali, Al-Tamimi, Jameel, Alomar, Suliman, Mansour, Lamjed
Format Journal Article
LanguageEnglish
Published England Taylor & Francis Group 01.12.2024
Subjects
acute myeloid leukemia
CTLA-4
CTLA-4 Antigen
Hematological malignancy
Hepatitis A Virus Cellular Receptor 2
Humans
Immune checkpoint molecules
Leukemia, Myeloid, Acute
Polymorphism, Single Nucleotide
Saudi Arabia
single nucleotide polymorphism
TIM-3
Saudi Arabia
Saudi Arabia
acute myeloid leukemia
Immune checkpoint molecules
single nucleotide polymorphism
CTLA-4
TIM-3
Hematological malignancy
Online AccessGet full text

Cover

More Information
Summary:Immune checkpoints are receptors on the surface of T cells that function crucially in suppressing the immune response, and they are implicated in autoimmunity and cancer diseases. The present study aimed to investigate the relationship between functional single nucleotide polymorphisms (SNPs) of two immune checkpoint molecules, CTLA-4 and TIM-3, and acute myeloid leukemia (AML) in a Saudi population. Two SNPs in (rs231775, A > G) and (rs10515746, A > C) were genotyped in 229 subjects, including 98 patients and 131 healthy controls, from the Saudi population using TaqMan assay methods. Differential expression of these two genes was performed using in silico analysis. An association was found between polymorphisms in (OR: 6.01; 95% CI: 3.99-9.05,  < 0.0001) and the risk of AML. Inversely, the rs231775 SNP in the gene was found to protect against AML in allelic, dominant, and additive models (  < 0.05). A significantly higher expression of in the blood of individuals with AML was observed. This is the first study focusing on single nucleotide polymorphisms (SNPs) for and in acute myeloid leukemia patients in a Saudi community and could be a potential new prognostic factor for this disease.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1607-8454
1607-8454
DOI:10.1080/16078454.2024.2329024