Resistance to macrolides in Group A streptococci from the European section of Turkey: genetic and phenotypic characterization

The aim of this study was to determine the susceptibilities to macrolides of Group A streptococcal isolates from the European section of Turkey. In the case of resistant isolates, the patterns and genetic mechanisms of erythromycin resistance were studied. Seven (2.7%) of the 260 isolates were resis...

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Published inInternational journal of antimicrobial agents Vol. 20; no. 6; pp. 461 - 463
Main Authors Akata, Filiz, Öztürk, Devrim, Tansel, Özlem, Tatman-Otkun, Müserref, Otkun, Metin, Fitoussi, Frederic, Bingen, Edouard, Tugrul, Murat
Format Journal Article
LanguageEnglish
Published London Elsevier B.V 01.12.2002
Amsterdam Elsevier
New York, NY
Subjects
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Drug Resistance, Multiple, Bacterial - genetics
ermTR
Erythromycin - pharmacology
Europe - ethnology
Group A streptococci
Humans
Macrolide resistance
Medical sciences
mefA
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Resistance phenotype
Streptococcal Infections - drug therapy
Streptococcal Infections - microbiology
Streptococcus pyogenes - drug effects
Streptococcus pyogenes - genetics
Turkey
Asia
Turkey
Europe
mefA
Group A streptococci
Resistance phenotype
Macrolide resistance
ermTR
Human
Streptococcaceae
Sensitivity resistance
Streptococcus A
Bacteria
Micrococcales
Antibacterial agent
Epidemiology
In vitro
Clinical isolate
Macrolide
Biological activity
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Summary:The aim of this study was to determine the susceptibilities to macrolides of Group A streptococcal isolates from the European section of Turkey. In the case of resistant isolates, the patterns and genetic mechanisms of erythromycin resistance were studied. Seven (2.7%) of the 260 isolates were resistant to erythromycin. Four of them showed the M phenotype and harboured mefA genes whereas three isolates showed the inducible macrolide, lincosamide and streptogramin B resistance phenotype and harboured ermTR genes. In the European section of Turkey, the current resistance rate of Group A streptococci to macrolides remains low.
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ISSN:0924-8579
1872-7913
DOI:10.1016/S0924-8579(02)00241-8