Molecular epidemiology and antibiotic resistance of Enterobacter spp. from three distinct populations in Grampian, UK

The distribution of Enterobacter spp. within the population of Aberdeen Royal Infirmary was compared with the outpatient population with regard to molecular epidemiology and antibiotic resistance. Enterobacter spp. from 60 patients and one environmental site were characterised as ITU, non ITU and ou...

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Bibliographic Details
Published inInternational journal of antimicrobial agents Vol. 20; no. 6; pp. 419 - 425
Main Authors Wagenlehner, F.M.E, MacKenzie, F.M, Forbes, K.J, Gould, I.M
Format Journal Article
LanguageEnglish
Published London Elsevier B.V 01.12.2002
Amsterdam Elsevier
New York, NY
Subjects
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotic resistance
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Clonal relationship
Cross Infection - epidemiology
Cross Infection - microbiology
Drug Resistance, Bacterial - genetics
Enterobacter - drug effects
Enterobacter - genetics
Enterobacter spp
Enterobacteriaceae Infections - epidemiology
Enterobacteriaceae Infections - microbiology
Humans
Intensive Care Units
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Phylogeny
Serotyping
United Kingdom - epidemiology
England
United Kingdom
Great Britain
Europe
Clonal relationship
Enterobacter spp
Antibiotic resistance
Human
Enterobacter
Sensitivity resistance
Bacteria
Genotype
Antibacterial agent
Epidemiology
In vitro
Clinical isolate
Biological activity
Enterobacteriaceae
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Summary:The distribution of Enterobacter spp. within the population of Aberdeen Royal Infirmary was compared with the outpatient population with regard to molecular epidemiology and antibiotic resistance. Enterobacter spp. from 60 patients and one environmental site were characterised as ITU, non ITU and outpatients’ isolates. Thirty-five percent were blood culture isolates. Cefotaxime resistant strains in the hospital were frequent. Cefotaxime (64%) sensitive isolates were inducible for hyperproduction of Bush group 1 β-lactamase. Isolates were further investigated by PFGE. Isolates (27%) were clonally related and typed in four clusters. Consecutive isolates were studied in selected patients showing minor genomic changes. One environmental isolate from a deep sink at ITU was related to a patient's isolate.
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ISSN:0924-8579
1872-7913
DOI:10.1016/S0924-8579(02)00179-6