Heliopsis longipes: anti-arthritic activity evaluated in a Freund's adjuvant-induced model in rodents

[Display omitted] This study assesses the anti-arthritic effect of the affinin-enriched (spilanthol, main alkamide) hexane extract from the roots of Heliopsis longipes (A. Gray) S.F. Blake, Asteraceae, on a Freund adjuvant-induced arthritis model in rodents. The extract was orally administered at a...

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Published inRevista brasileira de farmacognosia Vol. 27; no. 2; pp. 214 - 219
Main Authors Escobedo-Martínez, Carolina, Guzmán-Gutiérrez, Silvia Laura, Hernández-Méndez, María de los Milagros, Cassani, Julia, Trujillo-Valdivia, Alfonso, Orozco-Castellanos, Luis Manuel, Enríquez, Raúl G.
Format Journal Article
LanguageEnglish
Published Cham Elsevier Editora Ltda 01.03.2017
Springer International Publishing
Sociedade Brasileira de Farmacognosia
Subjects
Affinin
Anti-arthritic
Complete Freund adjuvant
Heliopsis longipes
Original Article
PHARMACOLOGY & PHARMACY
Pharmacy
Spilanthol
Affinin
Spilanthol
Heliopsis longipes
Complete Freund adjuvant
Anti-arthritic
Complete Freund
adjuvant
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Summary:[Display omitted] This study assesses the anti-arthritic effect of the affinin-enriched (spilanthol, main alkamide) hexane extract from the roots of Heliopsis longipes (A. Gray) S.F. Blake, Asteraceae, on a Freund adjuvant-induced arthritis model in rodents. The extract was orally administered at a dose of 2, 6.6, or 20mg/kg; a significant edema-inhibitory activity in the acute and chronic phases was observed with a dose of 2 and 20mg/kg, respectively. The extract showed higher anti-inflammatory and anti-arthritic effects than the reference drug phenylbutazone (80mg/kg). Moreover, the extract prevented the occurrence of secondary lesions associated to this pharmacological model.
ISSN:0102-695X
1981-528X
1981-528X
DOI:10.1016/j.bjp.2016.09.003