Insulin sensitivity in Type 2 diabetes: univariate and multivariate techniques to derive estimates of insulin sensitivity from the insulin modified intravenous glucose tolerance test (FSIGT)

• Published in: Computer methods and programs in biomedicine Vol. 68; no. 2; pp. 161 - 176
• Main Authors: Mehring, Guenther H., Coates, Philip A., Brunel, Patrick C., Luzio, Stephen D., Owens, David R.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.05.2002; Elsevier Science
• Subjects: Aged; Analysis of Variance; Biological and medical sciences; Blood Glucose - metabolism; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - metabolism; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Glucose Clamp Technique - statistics & numerical data; Glucose Tolerance Test - statistics & numerical data; Humans; Insulin - administration & dosage; Insulin - blood; Insulin Resistance; Intravenous glucose tolerance test; Investigative techniques, diagnostic techniques (general aspects); Isoglycaemic hyperinsulinaemic clamp; Male; Medical sciences; Metabolic diseases; Middle Aged; Multivariate Analysis; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Type 2 diabetic subjects; Isoglycaemic hyperinsulinaemic clamp; Type 2 diabetic subjects; Intravenous glucose tolerance test; Endocrinopathy; Human; Evaluation; Tolerance test; Glucose tolerance test; Glucose; Multivariate analysis; Screening test; Non insulin dependent diabetes; Insulin; Sensitivity; Reproducibility; Comparative study
• ISSN: 0169-2607; 1872-7565
• DOI: 10.1016/S0169-2607(01)00169-9

The use of univariate and multivariate techniques to derive estimates of insulin sensitivity from the insulin modified FSIGT were investigated in 12 Type 2 diabetic subjects aged (mean±S.D.) 59±9.5 years and BMI 28.1±2.2 kg m −2, who underwent both a FSIGT and an isoglycemic hyperinsulinemic clamp. Reproducibility of the FSIGT was tested in four patients on three separate occasions. FSIGT data were assessed by both univariate and multivariate techniques. The sensitivity index for the FSIGT ranged from 0.162 to 3.292 (mean 1.378)×10 −4·l min −1 mU −1 for the univariate approach and from 0.163 to 2.727 (mean 1.378)×10 −4·l min −1 mU −1 for the multivariate method. Mean S Iclamp was 44.41×10 −4·l −2 min −1·mU −1 (range 22.0–77.92). The correlation of the insulin sensitivity indices between the clamp and the FSIGT was 0.51 ( P=0.056) for the univariate and 0.67 ( P=0.017) for the multivariate analyses. Repeated FSIGTs showed a lower variability for the multivariate than for the standard approach.