Human papillomavirus infection and the multistage carcinogenesis of cervical cancer

This short review outlines our understanding of cervical cancer precursors, concentrating on the central etiologic role of persistent human papillomavirus infection. The stages of cervical carcinogenesis are better understood than for most other major cancers, providing a successful cancer etiology...

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Bibliographic Details
Published inCancer epidemiology, biomarkers & prevention Vol. 22; no. 4; pp. 553 - 560
Main Authors Schiffman, Mark, Wentzensen, Nicolas
Format Journal Article
LanguageEnglish
Published United States 01.04.2013
Subjects
Cell Transformation, Neoplastic - pathology
Disease Progression
Female
Humans
Papillomaviridae - pathogenicity
Papillomavirus Infections - pathology
Papillomavirus Infections - virology
Risk Factors
Uterine Cervical Neoplasms - etiology
Uterine Cervical Neoplasms - pathology
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Summary:This short review outlines our understanding of cervical cancer precursors, concentrating on the central etiologic role of persistent human papillomavirus infection. The stages of cervical carcinogenesis are better understood than for most other major cancers, providing a successful cancer etiology and prevention model.
ISSN:1055-9965
1538-7755
DOI:10.1158/1055-9965.epi-12-1406