Metabolomics platforms for genome wide association studies—linking the genome to the metabolome

Graphical abstract Highlights ► Genome-wide association studies with metabolomics constitute mGWAS. ► mGWAS provide insights into genetic and environmental impact on metabolic processes. ► We review essential strategies for mGWAS. ► Examples of mGWAS in large cohort studies are discussed.

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Bibliographic Details
Published inCurrent opinion in biotechnology Vol. 24; no. 1; pp. 39 - 47
Main Authors Adamski, Jerzy, Suhre, Karsten
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2013
Subjects
amino acids
blood
carbohydrates
Cohort Studies
Environment
genetic variance
genome
Genome - genetics
genome-wide association study
Genome-Wide Association Study - methods
hormones
Humans
Internal Medicine
lipids
Metabolic Networks and Pathways - genetics
metabolome
Metabolome - genetics
metabolomics
Metabolomics - methods
Phenotype
screening
secondary metabolites
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Summary:Graphical abstract Highlights ► Genome-wide association studies with metabolomics constitute mGWAS. ► mGWAS provide insights into genetic and environmental impact on metabolic processes. ► We review essential strategies for mGWAS. ► Examples of mGWAS in large cohort studies are discussed.
Bibliography:http://dx.doi.org/10.1016/j.copbio.2012.10.003
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0958-1669
1879-0429
DOI:10.1016/j.copbio.2012.10.003