Isolated Langerhans cell histiocytosis of the thyroid in a female infant

Langerhans cell histiocytosis (LCH) involving the thyroid is very rare. It can be easily confused with far more common benign goiters or thyroid neoplasms. We report on a 5-month-old female patient presenting with progressive enlargement of an anterior neck mass. This patient underwent left subtotal...

Full description

Saved in:
Bibliographic Details
Published inEuropean journal of pediatrics Vol. 166; no. 11; pp. 1151 - 1153
Main Authors HUNG, Chia-Sui, YEH, Yuan-Chieh, CHEN, Jeng-Chang, JUNG, Shih-Ming, HUNG, Iou-Jih, LO, Fu-Sung
Format Journal Article
LanguageEnglish
Published Heidelberg Springer 01.11.2007
Berlin Springer Nature B.V
Subjects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Diagnosis, Differential
Female
General aspects
Hematologic and hematopoietic diseases
Histiocytosis, Langerhans-Cell - diagnosis
Histiocytosis, Langerhans-Cell - pathology
Histiocytosis, Langerhans-Cell - therapy
Humans
Infant
Medical sciences
Other diseases. Hematologic involvement in other diseases
Thyroid Diseases - diagnosis
Thyroid Diseases - pathology
Thyroid Diseases - therapy
Thyroid Gland - pathology
Thyroidectomy
Human
Pediatrics
Endocrine gland
Langerhans cell histiocytosis
Isolated cell
Female
Infant
Hemopathy
Thyroid gland
Online AccessGet full text

Cover

More Information
Summary:Langerhans cell histiocytosis (LCH) involving the thyroid is very rare. It can be easily confused with far more common benign goiters or thyroid neoplasms. We report on a 5-month-old female patient presenting with progressive enlargement of an anterior neck mass. This patient underwent left subtotal thyroidectomy following which a diagnosis of isolated LCH involving the thyroid gland was confirmed. A course of chemotherapy was administered, and oral thyroxine replacement was initiated. Eighteen months after this treatment, the patient remained in complete remission. Following a thorough review of the literature, as best we are aware, this patient is the youngest individual suffering LCH who has been reported in the literature. In conclusion, isolated LCH of the thyroid is rare, and its diagnosis can be challenging for a clinician and typically requires appropriate awareness. Local excision is the treatment of choice, and prolonged follow-up is recommended.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:0340-6199
1432-1076
DOI:10.1007/s00431-006-0397-4