Serotonin, locomotion, exploration, and place recall in the rat

• Published in: Pharmacology, biochemistry and behavior Vol. 75; no. 2; pp. 381 - 395
• Main Authors: Mogensen, Jesper, Wörtwein, Gitta, Plenge, Per, Mellerup, Erling T.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.05.2003; Elsevier Science
• Subjects: 5,7-Dihydroxytryptamine; 5,7-Dihydroxytryptamine - pharmacology; Activity cage; Alzheimer's dementia; Amphetamine - pharmacology; Animals; Behavioral psychophysiology; Biological and medical sciences; Brain Chemistry - drug effects; Brain Chemistry - physiology; Brain damage recovery; Central Nervous System Stimulants - pharmacology; Cognitive functions; Exploratory Behavior - physiology; Fundamental and applied biological sciences. Psychology; Male; Maze Learning - drug effects; Mental Recall - physiology; Motor Activity - physiology; Muscarinic Antagonists - pharmacology; Neurochemical systems interaction; Neurotransmission and behavior; Norepinephrine Plasma Membrane Transport Proteins; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A - drug effects; Receptor, Serotonin, 5-HT1B - drug effects; Receptor, Serotonin, 5-HT2A - drug effects; Receptors, Adrenergic, beta - drug effects; Scopolamine - pharmacology; Serotonin; Serotonin - physiology; Serotonin Uptake Inhibitors - pharmacology; Symporters - metabolism; Vertical hole-board; Water maze; Activity cage; Neurochemical systems interaction; Vertical hole-board; Serotonin; Cognitive functions; Alzheimer's dementia; Water maze; 5,7-Dihydroxytryptamine; Brain damage recovery; Rat; Alzheimer disease; Cognition; Serotonine receptor; Learning; Acquisition process; Degenerative disease; Behavior; Psychophysiology; Nervous system diseases; Rodentia; Instrumental conditioning; Gene expression; Cerebral disorder; Vertebrata; Mammalia; Animal activity; Depletion; Animal; Central nervous system disease; Lesion; Neurotransmission
• ISSN: 0091-3057; 1873-5177
• DOI: 10.1016/S0091-3057(03)00107-2

Intracerebroventricular injection of 5,7-dihydroxytryptamine (5,7-DHT) led to a 90% reduction of the 5-hydroxytryptamine (5-HT) reuptake site. Behavioural symptoms were studied early (45 to 93 h) as well as late (11 to 14 days) in the postoperative period. Forty-five hours postoperatively, recall of a place navigation task in a water maze was clearly impaired in 5,7-DHT-treated animals. This impairment had disappeared by the fifth postoperative session. During the early test period, injection of scopolamine (0.5 mg/kg) or d-amphetamine (3.0 mg/kg) did not affect place recall of the vehicle-treated control group. In contrast, 5,7-DHT-treated animals were impaired by administration of scopolamine, but not d-amphetamine. During the late test period, the place recall of both groups was affected by scopolamine, but only the performance of the 5,7-DHT lesioned animals was sensitive to d-amphetamine. Locomotion was not severely affected at any time after 5,7-DHT treatment. The vertical hole-board test indicated that the exploratory activities of the animals were relatively unaffected by 5,7-DHT when measured 48 h postoperatively. At 14 days postsurgery, the 5,7-DHT-treated animals demonstrated an impaired habituation of the exploratory behaviour.