Amide bond formation via C(sp(3))-H bond functionalization and CO insertion

An efficient method for the synthesis of amides via Pd-catalyzed oxidative carbonylation of C(sp(3))-H bonds with CO and amines is described. The route efficiently provides substituted phenyl amides from alkanes.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 50; no. 3; pp. 341 - 343
Main Authors Liu, Huizhen, Laurenczy, Gabor, Yan, Ning, Dyson, Paul J.
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2014
Subjects
Alkanes
Alkanes - chemistry
Amides - chemical synthesis
Amides - chemistry
Aniline Compounds - chemistry
Carbon - chemistry
Catalysis
Chemistry
Chemistry, Multidisciplinary
Hydrogen
Ketones - chemistry
Oxidation-Reduction
Palladium - chemistry
Physical Sciences
Quantum Theory
Science & Technology
PEPTIDES
CATALYZED OXIDATIVE CARBONYLATION
ACIDS
ARYL HALIDES
ANILINE
AMIDATION
H BONDS
AMINOCARBONYLATION
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Summary:An efficient method for the synthesis of amides via Pd-catalyzed oxidative carbonylation of C(sp(3))-H bonds with CO and amines is described. The route efficiently provides substituted phenyl amides from alkanes.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc47015f