mCPP-induced hypophagia in rats is unaffected by the profile of dietary unsaturated fatty acids

• Published in: Pharmacology, biochemistry and behavior Vol. 73; no. 3; pp. 545 - 550
• Main Authors: Rice, H.B, Corwin, R.L
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.10.2002; Elsevier Science
• Subjects: 5-HT 2C; Agonist; Animals; Biological and medical sciences; Body Weight - drug effects; Diet; Dietary Fats - pharmacology; Dose-Response Relationship, Drug; Energy Intake - drug effects; Essential fatty acid; Fat; Fatty Acids, Omega-3 - pharmacology; Fatty Acids, Unsaturated - pharmacology; Feeding Behavior - drug effects; Flaxseed; Food intake; General and cellular metabolism. Vitamins; Ingestive behavior; Linoleic acid; Linolenic acid; Male; Medical sciences; Neuropharmacology; Neurotransmitters. Neurotransmission. Receptors; Pharmacology. Drug treatments; Piperazines - pharmacology; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin - drug effects; Safflower; Serotonin; Serotonin Receptor Agonists - pharmacology; Serotoninergic system; Safflower; Agonist; Linolenic acid; Flaxseed; Serotonin; Food intake; Fat; Ingestive behavior; Essential fatty acid; 5-HT 2C; Linoleic acid; Intraperitoneal administration; Feeding behavior; Rat; Body weight; Rodentia; Biological activity; Vertebrata; Mammalia; Animal; 5-HT1B serotonin receptor; Unsaturated fatty acid; Anorectic; Piperazine derivatives; 5-HT2C serotonin receptor
• ISSN: 0091-3057; 1873-5177
• DOI: 10.1016/S0091-3057(02)00839-0

The n-3 and n-6 polyunsaturated fatty acids (PUFAs) have been shown to modify central serotonergic parameters relevant to ingestive behavior. Evidence suggests an association between the 5-HT 2C receptor and fat intake. The present research sought to examine the role of the 5-HT 2C receptor subtype on food intake when diets with different fatty acid compositions are consumed. The effects of 1-(3-chlorophenyl)piperazine (mCPP) on consumption of both low-fat (Experiment 1) and high-fat diets (Experiment 2) differing in their predominant PUFA profiles were compared in rats. Regardless of the PUFA profile, mCPP induced hypophagia within each experiment. Although the present results lend further support to a large body of evidence demonstrating the ability of mCPP to reduce food intake, they do not support the idea that the essential fatty acid composition of the diet can differentially modulate mCPP-induced hypophagia.