Cold atmospheric plasma, a novel promising anti-cancer treatment modality

Over the past decade, cold atmospheric plasma (CAP), a near room temperature ionized gas has shown its promising application in cancer therapy. Two CAP devices, namely dielectric barrier discharge and plasma jet, show significantly anti-cancer capacity over dozens of cancer cell lines in vitro and s...

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Bibliographic Details
Published inOncotarget Vol. 8; no. 9; pp. 15977 - 15995
Main Authors Yan, Dayun, Sherman, Jonathan H, Keidar, Michael
Format Journal Article
LanguageEnglish
Published United States Impact Journals LLC 28.02.2017
Subjects
Cold Temperature
Humans
Neoplasms - therapy
Plasma Gases - therapeutic use
Review
selectivity
cancer treatment
reactive species
cold plasma
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Summary:Over the past decade, cold atmospheric plasma (CAP), a near room temperature ionized gas has shown its promising application in cancer therapy. Two CAP devices, namely dielectric barrier discharge and plasma jet, show significantly anti-cancer capacity over dozens of cancer cell lines in vitro and several subcutaneous xenograft tumors in vivo. In contrast to conventional anti-cancer approaches and drugs, CAP is a selective anti-cancer treatment modality. Thus far establishing the chemical and molecular mechanism of the anti-cancer capacity of CAP is far from complete. In this review, we provide a comprehensive introduction of the basics of CAP, state of the art research in this field, the primary challenges, and future directions to cancer biologists.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.13304