EFFECTS OF CHRONIC TREATMENT WITH TESTOSTERONE PROPIONATE ON AGGRESSION AND HORMONAL LEVELS IN INTACT MALE MICE

Effects of testosterone propionate, an anabolic-androgenic steroid (AAS), on aggression in gonadally intact male mice were examined. Animals were given weekly injections of 3.75, 7.5, 15, and 30 mg/kg of drug or sesame oil for 10 weeks. During the last 3 weeks, behavioral tests were conducted and at...

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Published in	Psychoneuroendocrinology Vol. 23; no. 3; pp. 275 - 293
Main Authors	Martı́nez-Sanchis, S, Salvador, A, Moya-Albiol, L, González-Bono, E, Simón, V.M
Format	Journal Article
Language	English
Published	Oxford Elsevier Ltd 01.04.1998 Elsevier
Subjects	AAS Aggression Aggression - drug effects Agonistic Behavior - drug effects Anabolic Agents - pharmacology Animals Arousal - drug effects Behavioral psychophysiology Biological and medical sciences Corticosterone Corticosterone - blood Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Hormones and behavior Individual differences Individuality Intact male mice Male Mice Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Social Behavior Testosterone Testosterone - blood Testosterone - pharmacology Intact male mice Testosterone AAS Corticosterone Aggression Individual differences Androgen Defensive behavior Body weight Rodentia Male Testicle Male genital system Multiple dose Vertebrata Mammalia Mouse Social interaction Conflict Animal Interindividual comparison Testicular hormone Sex steroid hormone Aggressiveness Agonistic behavior
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Abstract	Effects of testosterone propionate, an anabolic-androgenic steroid (AAS), on aggression in gonadally intact male mice were examined. Animals were given weekly injections of 3.75, 7.5, 15, and 30 mg/kg of drug or sesame oil for 10 weeks. During the last 3 weeks, behavioral tests were conducted and at the end of the experiment, body, liver and testes weight and hormonal data were collected. The treatment had minimal behavioral and endocrine effects. It resulted in shorter latencies of ‘threat’ only in the last agonistic encounter, increases in testosterone levels and decreases in testes weight in a non-linear dose-dependant way. The action of the treatment was different on threat and attack, the latter being unaffected. The behavioral effects in the total sample were only found in aggressive animals selected on the basis of their latency of attack in the first encounter. © 1998 Elsevier Science Ltd. All rights reserved.
AbstractList	Effects of testosterone propionate, an anabolic-androgenic steroid (AAS), on aggression in gonadally intact male mice were examined. Animals were given weekly injections of 3.75, 7.5, 15, and 30 mg/kg of drug or sesame oil for 10 weeks. During the last 3 weeks, behavioral tests were conducted and at the end of the experiment, body, liver and testes weight and hormonal data were collected. The treatment had minimal behavioral and endocrine effects. It resulted in shorter latencies of `threat' only in the last agonistic encounter, increases in testosterone levels and decreases in testes weight in a non-linear dose-dependant way. The action of the treatment was different on threat and attack, the latter being unaffected. The behavioral effects in the total sample were only found in aggressive animals selected on the basis of their latency of attack in the first encounter. Effects of testosterone propionate, an anabolic-androgenic steroid (AAS), on aggression in gonadally intact male mice were examined. Animals were given weekly injections of 3.75, 7.5, 15, and 30 mg/kg of drug or sesame oil for 10 weeks. During the last 3 weeks, behavioral tests were conducted and at the end of the experiment, body, liver and testes weight and hormonal data were collected. The treatment had minimal behavioral and endocrine effects. It resulted in shorter latencies of 'threat' only in the last agonistic encounter, increases in testosterone levels and decreases in testes weight in a non-linear dose-dependant way. The action of treatment was different on threat and attack, the latter being unaffected. The behavioral effects in the total sample were only found in aggressive animals selected on the basis of their latency of attack in the first encounter. Effects of testosterone propionate, an anabolic-androgenic steroid (AAS), on aggression in gonadally intact male mice were examined. Animals were given weekly injections of 3.75, 7.5, 15, and 30 mg/kg of drug or sesame oil for 10 weeks. During the last 3 weeks, behavioral tests were conducted and at the end of the experiment, body, liver and testes weight and hormonal data were collected. The treatment had minimal behavioral and endocrine effects. It resulted in shorter latencies of ‘threat’ only in the last agonistic encounter, increases in testosterone levels and decreases in testes weight in a non-linear dose-dependant way. The action of the treatment was different on threat and attack, the latter being unaffected. The behavioral effects in the total sample were only found in aggressive animals selected on the basis of their latency of attack in the first encounter. © 1998 Elsevier Science Ltd. All rights reserved.
Author	Salvador, A Simón, V.M Martı́nez-Sanchis, S González-Bono, E Moya-Albiol, L
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Keywords	Intact male mice Testosterone AAS Corticosterone Aggression Individual differences Androgen Defensive behavior Body weight Rodentia Male Testicle Male genital system Multiple dose Vertebrata Mammalia Mouse Social interaction Conflict Animal Interindividual comparison Testicular hormone Sex steroid hormone Aggressiveness Agonistic behavior
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Snippet	Effects of testosterone propionate, an anabolic-androgenic steroid (AAS), on aggression in gonadally intact male mice were examined. Animals were given weekly...
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SubjectTerms	AAS Aggression Aggression - drug effects Agonistic Behavior - drug effects Anabolic Agents - pharmacology Animals Arousal - drug effects Behavioral psychophysiology Biological and medical sciences Corticosterone Corticosterone - blood Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Hormones and behavior Individual differences Individuality Intact male mice Male Mice Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Social Behavior Testosterone Testosterone - blood Testosterone - pharmacology
Title	EFFECTS OF CHRONIC TREATMENT WITH TESTOSTERONE PROPIONATE ON AGGRESSION AND HORMONAL LEVELS IN INTACT MALE MICE
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