EFFECTS OF CHRONIC TREATMENT WITH TESTOSTERONE PROPIONATE ON AGGRESSION AND HORMONAL LEVELS IN INTACT MALE MICE

• Published in: Psychoneuroendocrinology Vol. 23; no. 3; pp. 275 - 293
• Main Authors: Martı́nez-Sanchis, S, Salvador, A, Moya-Albiol, L, González-Bono, E, Simón, V.M
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.04.1998; Elsevier
• Subjects: AAS; Aggression; Aggression - drug effects; Agonistic Behavior - drug effects; Anabolic Agents - pharmacology; Animals; Arousal - drug effects; Behavioral psychophysiology; Biological and medical sciences; Corticosterone; Corticosterone - blood; Dose-Response Relationship, Drug; Fundamental and applied biological sciences. Psychology; Hormones and behavior; Individual differences; Individuality; Intact male mice; Male; Mice; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Social Behavior; Testosterone; Testosterone - blood; Testosterone - pharmacology; Intact male mice; Testosterone; AAS; Corticosterone; Aggression; Individual differences; Androgen; Defensive behavior; Body weight; Rodentia; Male; Testicle; Male genital system; Multiple dose; Vertebrata; Mammalia; Mouse; Social interaction; Conflict; Animal; Interindividual comparison; Testicular hormone; Sex steroid hormone; Aggressiveness; Agonistic behavior
• ISSN: 0306-4530; 1873-3360
• DOI: 10.1016/S0306-4530(98)00005-5

Effects of testosterone propionate, an anabolic-androgenic steroid (AAS), on aggression in gonadally intact male mice were examined. Animals were given weekly injections of 3.75, 7.5, 15, and 30 mg/kg of drug or sesame oil for 10 weeks. During the last 3 weeks, behavioral tests were conducted and at the end of the experiment, body, liver and testes weight and hormonal data were collected. The treatment had minimal behavioral and endocrine effects. It resulted in shorter latencies of ‘threat’ only in the last agonistic encounter, increases in testosterone levels and decreases in testes weight in a non-linear dose-dependant way. The action of the treatment was different on threat and attack, the latter being unaffected. The behavioral effects in the total sample were only found in aggressive animals selected on the basis of their latency of attack in the first encounter. © 1998 Elsevier Science Ltd. All rights reserved.