Human Monocytes: Distinct Receptor Sites for the Third Component of Complement and for Immunoglobulin G
Human monocytes contain two distinct receptor sites, one specific for the third component of complement (C′3), the other for immunoglobulin G (γG). The two receptors may function either independently or cooperatively in the induction of phagocytosis. Ingestion of erythrocytes coated with immunoglobu...
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Published in | Science (American Association for the Advancement of Science) Vol. 162; no. 3859; pp. 1281 - 1283 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Association for the Advancement of Science
13.12.1968
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Subjects | |
Online Access | Get full text |
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Summary: | Human monocytes contain two distinct receptor sites, one specific for the third component of complement (C′3), the other for immunoglobulin G (γG). The two receptors may function either independently or cooperatively in the induction of phagocytosis. Ingestion of erythrocytes coated with immunoglobulin M antibody requires a relatively large number of bound C′3 molecules per cell. Ingestion of erythrocytes sensitized with γG antibody is independent of complement; however, the reaction is inhibited by concentrations of γ G far below those in normal serum. Inhibition by γG-globulin is overcome by a relatively small number of bound C′3 molecules per cell. The two monocyte receptors exert a cooperative effect on ingestion by monocytes of erythrocytes coated with γG antibody in the presence of inhibitory amounts of free ′G. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0036-8075 1095-9203 |
DOI: | 10.1126/science.162.3859.1281 |