The effects of protein corona on in vivo fate of nanocarriers

• Published in: Advanced drug delivery reviews Vol. 186; p. 114356
• Main Authors: Xiao, Qingqing, Zoulikha, Makhloufi, Qiu, Min, Teng, Chao, Lin, Chenshi, Li, Xiaotong, Sallam, Marwa A., Xu, Qiaobing, He, Wei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2022
• Subjects: Drug delivery; In vivo fate; Nanoparticles; Protein corona; Protein-nanomaterial interaction; RES; BBB; NSPs; LNP; UV–vis; BSA; LC-MS/MS; Tf; FBS; HSA; HBP; MNPs; RNAi; AD; SWCNTs; MW; PGA; PDMA; NRs; OEG; SDS-PAGE; NC; In vivo fate; MWCNTs; LCST; OVA; Ig; PCS; ABC; FDA; PPC; Drug delivery; DLS; SNAs; HRG 4; NSs; Nanoparticles; HER 2; LDL; β-lg; pI; Protein corona; CD; DSPE; PHPMA; VEGF; PMC; Protein-nanomaterial interaction; MSN; siRNA; Apos; NIPAm; NPs; PC; PEG; PLGA; PK; TEM

The nanoparticles interact with the biomaterials in biological fluids, resulting in protein corona formation that may influence their properties and in vivo fate. The design strategies of drug delivery systems have been expanded due to the better understanding of protein corona composition and the i...