The effects of protein corona on in vivo fate of nanocarriers

• Published in: Advanced drug delivery reviews Vol. 186; p. 114356
• Main Authors: Xiao, Qingqing, Zoulikha, Makhloufi, Qiu, Min, Teng, Chao, Lin, Chenshi, Li, Xiaotong, Sallam, Marwa A., Xu, Qiaobing, He, Wei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2022
• Subjects: Drug delivery; In vivo fate; Nanoparticles; Protein corona; Protein-nanomaterial interaction; RES; BBB; NSPs; LNP; UV–vis; BSA; LC-MS/MS; Tf; FBS; HSA; HBP; MNPs; RNAi; AD; SWCNTs; MW; PGA; PDMA; NRs; OEG; SDS-PAGE; NC; In vivo fate; MWCNTs; LCST; OVA; Ig; PCS; ABC; FDA; PPC; Drug delivery; DLS; SNAs; HRG 4; NSs; Nanoparticles; HER 2; LDL; β-lg; pI; Protein corona; CD; DSPE; PHPMA; VEGF; PMC; Protein-nanomaterial interaction; MSN; siRNA; Apos; NIPAm; NPs; PC; PEG; PLGA; PK; TEM
• ISSN: 0169-409X; 1872-8294; 1872-8294
• DOI: 10.1016/j.addr.2022.114356

The nanoparticles interact with the biomaterials in biological fluids, resulting in protein corona formation that may influence their properties and in vivo fate. The design strategies of drug delivery systems have been expanded due to the better understanding of protein corona composition and the interaction between nanoparticles and proteins. [Display omitted] With the emerging advances in utilizing nanocarriers for biomedical applications, a molecular-level understanding of the in vivo fate of nanocarriers is necessary. After administration into human fluids, nanocarriers can attract proteins onto their surfaces, forming an assembled adsorption layer called protein corona (PC). The formed PC can influence the physicochemical properties and subsequently determine nanocarriers' biological behaviors. Therefore, an in-depth understanding of the features and effects of the PC on the nanocarriers’ surface is the first and most important step towards controlling their in vivo fate. This review introduces fundamental knowledge such as the definition, formation, composition, conformation, and characterization of the PC, emphasizing the in vivo environmental factors that control the PC formation. The effect of PC on the physicochemical properties and thus biological behaviors of nanocarriers was then presented and thoroughly discussed. Finally, we proposed the design strategies available for engineering PC onto nanocarriers to manipulate them with the desired surface properties and achieve the best biomedical outcomes.