PPARs and the complex journey to obesity

Obesity and the related disorders of dyslipidemia and diabetes (components of syndrome X) have become global health epidemics. Over the past decade, the elucidation of key regulators of energy balance and insulin signaling have revolutionized our understanding of fat and sugar metabolism and their i...

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Published inNature medicine Vol. 10; no. 4; pp. 355 - 361
Main Authors Evans, Ronald M, Barish, Grant D, Wang, Yong-Xu
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.04.2004
Subjects
Adipocytes - physiology
Appetite - physiology
Diabetes Mellitus, Type 2 - physiopathology
Energy balance
Energy Metabolism - physiology
Epidemics
Global health
Glucose - physiology
Homeostasis - physiology
Humans
Insulin
Lipids - physiology
Metabolic disorders
Obesity
Obesity - physiopathology
Receptor, Insulin - metabolism
Receptors, Cytoplasmic and Nuclear - physiology
Signal Transduction - physiology
Sugar
Transcription Factors - physiology
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Summary:Obesity and the related disorders of dyslipidemia and diabetes (components of syndrome X) have become global health epidemics. Over the past decade, the elucidation of key regulators of energy balance and insulin signaling have revolutionized our understanding of fat and sugar metabolism and their intimate link. The three 'lipid-sensing' peroxisome proliferator-activated receptors (PPAR-alpha, PPAR-gamma and PPAR-delta) exemplify this connection, regulating diverse aspects of lipid and glucose homeostasis, and serving as bona fide therapeutic targets. With molecular underpinnings now in place, new pharmacologic approaches to metabolic disease and new questions are emerging.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1078-8956
1546-170X
DOI:10.1038/nm1025