Tumor Heterogeneity—A ‘Contemporary Concept’ Founded on Historical Insights and Predictions

Heterogeneity is commonplace in all cancer types and at several levels—intrinsic (genetic), epigenetic, positional, and at the population level. The different subpopulations with a tumor mass communicate with each other and influence the behavior of other tumor cells both locally and at a distance....

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Bibliographic Details
Published inCancer research (Chicago, Ill.) Vol. 76; no. 1; pp. 4 - 6
Main Author Welch, Danny R.
Format Journal Article
LanguageEnglish
Published United States 01.01.2016
Subjects
Genetic Heterogeneity
Humans
Neoplasms - genetics
Neoplasms - pathology
Tumor Microenvironment
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Summary:Heterogeneity is commonplace in all cancer types and at several levels—intrinsic (genetic), epigenetic, positional, and at the population level. The different subpopulations with a tumor mass communicate with each other and influence the behavior of other tumor cells both locally and at a distance. These properties have profound implications regarding the understanding of tumor behavior and how therapies are (or should be) administered. This brief commentary highlights the insightful review of Gloria Heppner and how it has influenced cancer research even three decades after it was published. Cancer Res; 76(1); 4–6. ©2016 AACR. See related article by Heppner, Cancer Res 1984;44:2259-65.
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ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.CAN-15-3024