Patterns of failure and clinical outcomes of definitive radiotherapy for cervical esophageal cancer

• Published in: Oncotarget Vol. 8; no. 13; pp. 21852 - 21860
• Main Authors: Zhao, Lina, Zhou, Yongchun, Mu, Yunfeng, Chai, Guangjin, Xiao, Feng, Tan, Lina, Lin, Steven H, Shi, Mei
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 28.03.2017
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - radiotherapy; Disease-Free Survival; Esophageal Neoplasms - mortality; Esophageal Neoplasms - radiotherapy; Esophageal Squamous Cell Carcinoma; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Proportional Hazards Models; Radiotherapy, Conformal; Research Paper; Retrospective Studies; Treatment Outcome; Young Adult; definitive radiotherapy; prophylactic irradiation; prognostic factor; cervical esophageal cancer; failure pattern
• ISSN: 1949-2553; 1949-2553
• DOI: 10.18632/oncotarget.15665

Because of the scarcity of cervical esophageal cancer (CEC), data for this disease entity is limited. We aim to evaluate the outcomes, prognostic factors and failure patterns of CEC treated by contemporary radiotherapy (RT). We retrospectively analyzed 86 CEC patients consecutively treated between 2007 and 2015 by definitive RT with or without concurrent chemotherapy. RT was mainly delivered with Intensity Modulated Irradiation Therapy (IMRT) or Volumetric-Modulated Arc Therapy (VMAT). Statistical analyses were performed on survival, prognostic factors and failure patterns. The median follow-up time was 19.4 months. The 3-year overall survival (OS), local regional failure free survival (LRFFS), distant metastatic free survival (DMFS), and progression free survival (PFS) were 53.6%, 57.9%, 81.5% and 41.5%, respectively. Independent predictors for poorer OS were N stage, hoarseness and recurrent laryngeal nerve lymph node (RLN) involvement, and predictors for LRFFS were N stage and EQD2 (equivalent dose in 2 Gy fraction) to gross tumor volume (GTV), with ≥ 66Gy achieving local control of 94.7%. Patients receiving elective nodal irradiation (ENI) had better nodal regional control than those receiving involved field irradiation (IFI). 31 (36%) patients had treatment failure and 15 (17.4%), 8 (9.3%) and 14 (16.2%) patients had local, regional, and distant failure, respectively. 86.7% (13/15) local failures were within GTV, and supraclavicular region (62.5%, 5/8) was the most common regional failure site. No severe toxicities were observed. Our results seem to indicate that good locoregional control might be achieved for CEC with adequate radiation dose and treatment planning approaches.