Characteristics of prefrontal activity during emotional and cognitive processing in patients with bipolar disorder: A multi-channel functional near-infrared spectroscopy study

Bipolar disorder (BD) is a recurrent chronic mental disorder with a broad profile of functional deficits including disturbed emotional processing and cognitive impairments. The goal of the current study was to further explore the underlying neural mechanism of dysfunction in patients with BD from a...

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Published inFrontiers in neuroscience Vol. 16; p. 946543
Main Authors Mao, Mengchai, Chen, Guifang, Feng, Kun, Xu, Dongsheng, Hua, Xuyun, Shan, Chunlei, Liu, Pozi
Format Journal Article
LanguageEnglish
Published Lausanne Frontiers Research Foundation 26.07.2022
Frontiers Media S.A
Subjects
Biomarkers
Bipolar disorder
Cognitive ability
emotion
Emotions
functional near-infrared spectroscopy
Hemoglobin
Hyperactivity
I.R. radiation
Information processing
Infrared spectroscopy
Magnetic resonance imaging
Medical imaging
Mental depression
Mental disorders
Neuroimaging
Neuroscience
Patients
prefrontal cortex
Spectrum analysis
verbal fluency
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Summary:Bipolar disorder (BD) is a recurrent chronic mental disorder with a broad profile of functional deficits including disturbed emotional processing and cognitive impairments. The goal of the current study was to further explore the underlying neural mechanism of dysfunction in patients with BD from a comprehensive perspective of both cognition and emotion. Forty-six clinical patients with BD and forty-five healthy controls performed emotion induction task and verbal fluency task (VFT), with frontal activity measured by functional near-infrared spectroscopy (fNIRS). Our results show distinct hemodynamic activity in the prefrontal region during emotional and cognitive processing between patients with BD and healthy controls. Patients with BD exhibit valence-dependent prefrontal cortex (PFC) hemodynamic response to emotional stimuli, with bilateral frontal hypoactivity indicating decreased positive reactivity and left frontal hyperactivity indicating increased negative reactivity. On the other hand, patients with BD showed impaired performance with bilateral frontal hypoactivity during VFT. Taken together, frontal dysfunction of cognition and emotionality in patients with BD probed by fNIRS would be a potential biomarker in clinical assessment.
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This article was submitted to Brain Imaging Methods, a section of the journal Frontiers in Neuroscience
Edited by: Zhengxia Wang, Hainan University, China
Reviewed by: Hao Liu, JORU Rehabilitation Hospital, China; Qiang Gao, Sichuan University, China
These authors have contributed equally to this work and share first authorship
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2022.946543