An Update on Emergent Nano-Therapeutic Strategies against Pediatric Brain Tumors

Pediatric brain tumors are the major cause of pediatric cancer mortality. They comprise a diverse group of tumors with different developmental origins, genetic profiles, therapeutic options, and outcomes. Despite many technological advancements, the treatment of pediatric brain cancers has remained...

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Published inBrain sciences Vol. 14; no. 2; p. 185
Main Authors Ravi Kiran, Ammu V V V, Kumari, G Kusuma, Krishnamurthy, Praveen T, Johnson, Asha P, Kenchegowda, Madhuchandra, Osmani, Riyaz Ali M, Abu Lila, Amr Selim, Moin, Afrasim, Gangadharappa, H V, Rizvi, Syed Mohd Danish
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.02.2024
Subjects
Adults
Antimitotic agents
Antineoplastic agents
Blood-brain barrier
Brain cancer
Brain research
Brain tumors
Cancer
Cancer therapies
Care and treatment
Cell cycle
Chemotherapy
childhood cancers
Chromosomes
Ewings sarcoma
Gene amplification
Genomes
liposomes
Medical prognosis
Metastasis
Mutation
Nanoparticles
Patient compliance
Pediatrics
Tumors
childhood cancers
brain tumors
nanoparticles
liposomes
pediatrics
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Summary:Pediatric brain tumors are the major cause of pediatric cancer mortality. They comprise a diverse group of tumors with different developmental origins, genetic profiles, therapeutic options, and outcomes. Despite many technological advancements, the treatment of pediatric brain cancers has remained a challenge. Treatment options for pediatric brain cancers have been ineffective due to non-specificity, inability to cross the blood-brain barrier, and causing off-target side effects. In recent years, nanotechnological advancements in the medical field have proven to be effective in curing challenging cancers like brain tumors. Moreover, nanoparticles have emerged successfully, particularly in carrying larger payloads, as well as their stability, safety, and efficacy monitoring. In the present review, we will emphasize pediatric brain cancers, barriers to treating these cancers, and novel treatment options.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci14020185