Vitamin D receptor (VDR) gene polymorphism and osteoporosis risk in White British men
In this study, VDR gene (rs7975232), (rs 1544410) and (rs731236) genotypes were compared in men with osteoporosis and male controls. Osteoporosis affects around 20% of all men and overall mortality in the first year after hip fracture is significantly higher in men than women, yet the genetic basis...
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Published in | Annals of human biology Vol. 46; no. 5; pp. 430 - 433 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Taylor & Francis Group
04.07.2019
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Subjects | |
Online Access | Get full text |
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Summary: | In this study, VDR gene
(rs7975232),
(rs 1544410) and
(rs731236) genotypes were compared in men with osteoporosis and male controls. Osteoporosis affects around 20% of all men and overall mortality in the first year after hip fracture is significantly higher in men than women, yet the genetic basis of osteoporosis is less well studied in males. This study consisted of White British males; 69 osteoporosis patients and 122 controls. BMDs at the lumbar spine (vertebrae L1-L4) and hip (femur neck) were measured by dual-energy X-ray absorptiometry (DEXA). The VDR gene
,
and
genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and association analysis was carried out at genotype and haplotype level. Our study suggests that
polymorphism CC genotype frequency is lower in controls and further analysis of genotypes and BMD revealed a significant effect of
polymorphism on Lumbar spine BMD. Two haplotypes (GCC and AAT) were associated with increased osteoporosis risk. In conclusion, VDR gene
polymorphism in recessive mode had a significant effect on lumbar spine BMD within our study. Haplotypes GCC and AAT increase the risk of osteoporosis among White British males. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0301-4460 1464-5033 |
DOI: | 10.1080/03014460.2019.1659851 |