Small intestinal cancers among adults in an Egyptian district: A clinicopathological study using a population-based cancer registry

• Published in: Journal of Egyptian National Cancer Institute Vol. 25; no. 3; pp. 107 - 114
• Main Authors: Zeeneldin, Ahmed A., Saber, Magdy M., El-Din, Ibrahim A. Seif, Frag, Sara A.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Elsevier B.V 01.09.2013; Cairo University, National Cancer Institute
• Subjects: Adenocarcinoma - epidemiology; Adenocarcinoma - mortality; Adenocarcinoma - therapy; Adult; Aged; Cancer; Diseases; Duodenal Neoplasms - epidemiology; Duodenal Neoplasms - mortality; Duodenal Neoplasms - therapy; Egypt; Egypt - epidemiology; Female; Gharbiah population-based cancer registry; Humans; Ileal Neoplasms - epidemiology; Ileal Neoplasms - mortality; Ileal Neoplasms - therapy; Intestine, Small; Intestine, Small - pathology; Jejunal Neoplasms - epidemiology; Jejunal Neoplasms - mortality; Jejunal Neoplasms - therapy; Male; Middle Aged; Patients; Registries - statistics & numerical data; Retrospective Studies; Small intestinal neoplasms; Stomach; Survival; Treatment; Young Adult; الأمراض; الأمعاء الدقيقة; السرطان; المرضى; Egypt; Treatment; Gharbiah population-based cancer registry; Survival; Egypt; Small intestinal neoplasms
• ISSN: 1110-0362; 1687-9996; 2589-0409
• DOI: 10.1016/j.jnci.2013.01.004

Small intestinal cancers (SICs) are very rare all over the world and little is known about them in Egypt. This a retrospective study. Between 2000 and 2002, 30 cases with SICs were identified in the Gharbiah population based cancer registry (GPBCR); 17 cases of whom were treated at Tanta Cancer Center (TCC). The median age was 51years with female predominance. The duodenum was the commonest site (43%) followed by the ileum then the jejunum. Adenocarcinoma (AC), carcinoids, gastrointestinal stromal tumors (GISTs), lymphoma and sarcoma represented 50%, 10%, 17%, 13% and 10% respectively. Abdominal pain was the commonest symptom and localized disease was the commonest presentation. Surgery, chemotherapy and radiotherapy were employed in 65%, 35% and 0% of patients, respectively. The median overall survival and progression free survival (OS, PFS) were 18 and 15months (95% CI: 10.4–25.6 and 3.6–26.4), respectively. AC had inferior OS and PFS to other histologies (p=0.08 and 0.12, respectively). Also, duodenum subsite was inferior in OS and PFS to other sites (p=0.25 and 0.35, respectively). SICs in Gharbiah, Egypt are characterized by predominance of female gender and adenocarcinoma histology. One year survival is 64% with a poor outcome for adenocarcinoma and duodenal subsite.