Total Synthesis of Brevetoxin A: Part 1: First Generation Strategy and Construction of BCD Ring System

Dissection of brevetoxin A at the nine‐membered ring site (ring E) formed the basis of the first generation strategy for the total synthesis of this molecule. Unfortuately the planned hydroxy dithioketal cyclization to form the crucial nonacene did not proceed as anticipated and this approach was di...

Full description

Saved in:
Bibliographic Details
Published inChemistry : a European journal Vol. 5; no. 2; pp. 599 - 617
Main Authors Nicolaou, K. C., Bunnage, Mark E., McGarry, Daniel G., Shi, Shuhao, Somers, Patricia K., Wallace, Paul A., Chu, Xin-Jie, Agrios, Konstantinos A., Gunzner, Janet L., Yang, Zhen
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.02.1999
WILEY‐VCH Verlag
Wiley
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:Dissection of brevetoxin A at the nine‐membered ring site (ring E) formed the basis of the first generation strategy for the total synthesis of this molecule. Unfortuately the planned hydroxy dithioketal cyclization to form the crucial nonacene did not proceed as anticipated and this approach was discontinued.
Bibliography:istex:91114298672018C2EE8148F35F16F3E606A81311
ark:/67375/WNG-TZ4VNLLF-K
ArticleID:CHEM599
ISSN:0947-6539
1521-3765
DOI:10.1002/(SICI)1521-3765(19990201)5:2<599::AID-CHEM599>3.0.CO;2-N