Hyperspectral Imaging in Diabetic Foot Wound Care

Diabetic foot ulceration is a major complication of diabetes and afflicts as many as 15 to 25% of type 1 and 2 diabetes patients during their lifetime. If untreated, diabetic foot ulcers may become infected and require total or partial amputation of the affected limb. Early identification of tissue...

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Published inJournal of diabetes science and technology Vol. 4; no. 5; pp. 1099 - 1113
Main Authors Yudovsky, Dmitry, Nouvong, Aksone, Pilon, Laurent
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.09.2010
Diabetes Technology Society
SeriesFoot Technology, Part 2 of 2
Subjects
Blood Gas Monitoring, Transcutaneous - methods
Diabetic Foot - diagnosis
Diabetic Foot - metabolism
Diabetic Foot - physiopathology
Diagnostic Imaging - methods
Hemoglobins - metabolism
Humans
Oxyhemoglobins - metabolism
Skin - metabolism
Spectrum Analysis - methods
Symposium
Wound Healing - physiology
wound care
diabetic foot ulcer
tissue oximetry
hyperspectral imaging
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Summary:Diabetic foot ulceration is a major complication of diabetes and afflicts as many as 15 to 25% of type 1 and 2 diabetes patients during their lifetime. If untreated, diabetic foot ulcers may become infected and require total or partial amputation of the affected limb. Early identification of tissue at risk of ulcerating could enable proper preventive care, thereby reducing the incidence of foot ulceration. Furthermore, noninvasive assessment of tissue viability around already formed ulcers could inform the diabetes caregiver about the severity of the wound and help assess the need for amputation. This article reviews how hyperspectral imaging between 450 and 700 nm can be used to assess the risk of diabetic foot ulcer development and to predict the likelihood of healing noninvasively. Two methods are described to analyze the in vivo hyperspectral measurements. The first method is based on the modified Beer-Lambert law and produces a map of oxyhemoglobin and deoxyhemoglobin concentrations in the dermis of the foot. The second is based on a two-layer optical model of skin and can retrieve not only oxyhemoglobin and deoxyhemoglobin concentrations but also epidermal thickness and melanin concentration along with skin scattering properties. It can detect changes in the diabetic foot and help predict and understand ulceration mechanisms
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Funding: This research was funded in part through a grant from the National Institute of Diabetes and Digestive and Kidney Diseases (R42-DK069871).
ISSN:1932-2968
1932-2968
1932-3107
DOI:10.1177/193229681000400508