Radical Gastrectomy After Chemotherapy May Prolong Survival in Stage IV Gastric Cancer: A Korean Multi-institutional Analysis

• Published in: World journal of surgery Vol. 42; no. 10; pp. 3286 - 3293
• Main Authors: Seo, Ho Seok, Song, Kyo Young, Jung, Yoon Ju, Park, Seung Man, Jeon, Hae Myung, Kim, Wook, Chin, Hyung Min, Kim, Jin-Jo, Kim, Sung Keun, Chun, Kyung Hwa, Kim, Jeong Goo, Lee, Jun Hyun, Lee, Han Hong, Kim, Dong Jin, Yoo, Han Mo, Kim, Chang Hyun, Kim, Eun Young, Park, Cho Hyun
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.10.2018; Springer Nature B.V
• Subjects: Abdominal Surgery; Cancer; Cardiac Surgery; Chemotherapy; Gastrectomy; Gastric cancer; General Surgery; Life assessment; Medical prognosis; Medicine; Medicine & Public Health; Original Scientific Report; Patients; Surgery; Survival; Thoracic Surgery; Vascular Surgery
• ISSN: 0364-2313; 1432-2323
• DOI: 10.1007/s00268-018-4635-5

Abastract Background Despite the development of newer treatments, the prognosis for patients with stage IV gastric cancer remains grave. This study evaluated the efficacy of gastrectomy following response to chemotherapy in patients with stage IV gastric cancer. Methods A total of 419 patients who were diagnosed with stage IV gastric cancer were identified from the multi-institutional Catholic Gastric Cancer Study Group database. The patients were divided into four groups: 212 were in the chemotherapy only (CTx) group, 124 were in the chemotherapy after palliative gastrectomy (G-CTx) group, 23 were in the radical gastrectomy after chemotherapy (CTx-G) group, and 60 were in the best supportive care group. To compensate for the effects of chemotherapy, cases of chemotherapy responsive were analyzed separately. To identify factors affecting survival rates, cure rates for surgery in the surgery group were analyzed. Results The 3-year survival rate of the CTx-G group was significantly higher than that of the CTx group (42.8 vs. 12.0%, p  = 0.001). Moreover, the CTx-G group’s 3-year survival rate was greater than that of the G-CTx group (42.8 vs. 37.1%, p  = 0.207). Chemotherapy-responsive patients in the CTx-G group had a better 3-year survival rate than those in the G-CTx group (46.1 vs. 18.4%, respectively, p  = 0.011). In the surgery group, R0 resection led to a significantly better 3-year survival rate than palliative gastrectomy (61.1 vs. 16.2%, p  = 0.003). Conclusions Adjuvant surgery might improve the survival rate of patients with stage IV gastric cancer, particularly in R0 resection cases.