Autologous stem cell transplantation as first line treatment after incomplete excision of pancreatoblastoma

• Published in: Revista brasileira de hematologia e hemoterapia Vol. 35; no. 2; pp. 148 - 149
• Main Authors: Meneses, Clarice Franco, Osório, Carolina Dame, de Castro Junior, Claudio Galvão, Brunetto, Algemir Lunardi
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Associação Brasileira de Hematologia e Hemoterapia 2013; Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular; Elsevier
• Subjects: Case Report; Drug therapy, combination; HEMATOLOGY; Hematopoietic stem cell transplantation; MEDICINE, RESEARCH & EXPERIMENTAL; Pancreatic neoplasms; Pediatrics; Primary treatment; Pediatrics; Primary treatment; Drug therapy, combination; Hematopoietic stem cell transplantation; Pancreatic neoplasms
• ISSN: 1516-8484; 1806-0870; 1806-0870
• DOI: 10.5581/1516-8484.20130038

Pancreatoblastoma is a rare tumor and surgery with complete resection is the main treatment approach. Prognosis for patients with residual disease after surgery is usually dismal. A 14-year-old girl with pancreatoblastoma in the pancreatic body and tail was submitted to preoperative chemotherapy. She underwent surgery and the tumor was resected with microscopic margins. Postoperative chemotherapy was followed by high dose chemotherapy and autologous hematopoietic stem cell transplantation. After four years she remains very well with no evidence of disease. This is the first case reported of pancreatoblastoma that was treated with autologous hematopoietic stem cell transplantation as first line treatment without radiotherapy at the site of the microscopic disease.