Total Synthesis of Brevetoxin A: Part 4: Final Stages and Completion

A ten‐year campaign was successfully completed by the first total synthesis of brevetoxin A (1). A Horner–Wittig type coupling of suitably functionalized BCDE and GHIJ ring systems proved to be the last key step in the total synthesis of this architecturally beautiful molecule.

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Bibliographic Details
Published inChemistry : a European journal Vol. 5; no. 2; pp. 646 - 658
Main Authors Nicolaou, K. C., Gunzner, Janet L., Shi, Guo-qiang, Agrios, Konstantinos A., Gärtner, Peter, Yang, Zhen
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.02.1999
WILEY‐VCH Verlag
Wiley
Subjects
Brevetoxin A
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
Synthetic methods
Total synthesis
ORGANIC-SYNTHESIS
brevetoxin A
ACTIVATION
GENERATION STRATEGIES
CONSTRUCTION
PHOSPHATES
total synthesis
CYCLIC ETHERS
EPOXIDE OPENINGS
TETRAHYDROPYRAN SYSTEMS
TECHNOLOGY
synthetic methods
STEREOCONTROLLED SYNTHESIS
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Summary:A ten‐year campaign was successfully completed by the first total synthesis of brevetoxin A (1). A Horner–Wittig type coupling of suitably functionalized BCDE and GHIJ ring systems proved to be the last key step in the total synthesis of this architecturally beautiful molecule.
Bibliography:ArticleID:CHEM646
istex:87F24AC5DF545F19DA7B48D62385F99E93C0C67A
ark:/67375/WNG-32PQJ3B8-6
ISSN:0947-6539
1521-3765
DOI:10.1002/(SICI)1521-3765(19990201)5:2<646::AID-CHEM646>3.0.CO;2-E