A NEW TETRACYCLINE ANTIBIOTIC WITH ANTITUMOR ACTIVITY II. THE STRUCTURAL ELUCIDATION OF SF2575

The structure of a new antitumor antibiotic SF2575, has been determined by spectroscopic analyses of the antibiotic and its alkaline degradation products. The relative stereochemistry has been confirmed by X-ray crystallographic analysis. The antibiotic has a 2-naphthacenecarboxamide carbon skelton...

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Published inJournal of antibiotics Vol. 45; no. 3; pp. 325 - 330
Main Authors HATSU, MASAHIRO, SASAKI, TORU, GOMI, SHUICHI, KODAMA, YOSHIO, SEZAKI, MASAJI, INOUYE, SHIGEHARU, KONDO, SHINICHI
Format Journal Article
LanguageEnglish
Published Japan JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1992
Subjects
Antibiotics, Antineoplastic - chemistry
Molecular Conformation
Streptomyces
Tetracyclines - chemistry
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Summary:The structure of a new antitumor antibiotic SF2575, has been determined by spectroscopic analyses of the antibiotic and its alkaline degradation products. The relative stereochemistry has been confirmed by X-ray crystallographic analysis. The antibiotic has a 2-naphthacenecarboxamide carbon skelton which is structurally related to the tetracycline antibiotics and it is unique by bearing C-glycoside, salicylic acid and angelic acid moieties.
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ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.45.325