Increased levels of air pollution and a decrease in the human and mouse male-to-female ratio in São Paulo, Brazil

A significant negative association ( R2 = 0.7642; P =.013) between particulate matter and secondary sex ratio was found when evaluating people in the city of São Paulo, Brazil. An animal model with male mice raised in nonfiltered open-top chambers showed a significant reduction in the secondary sex...

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Published inFertility and sterility Vol. 87; no. 1; pp. 230 - 232
Main Authors Lichtenfels, Ana Julia F.C., M.Sc, Gomes, Joabner B., M.Sc, Pieri, Patrícia C., M.Sc, El Khouri Miraglia, Simone G., M.Sc, Hallak, Jorge, M.D, Saldiva, Paulo H.N., M.D
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 2007
Elsevier Science
Subjects
Air Pollution - analysis
Air Pollution - statistics & numerical data
Animals
Biological and medical sciences
Brazil - epidemiology
Cities - statistics & numerical data
Female
Gynecology. Andrology. Obstetrics
Humans
Internal Medicine
Male
Medical sciences
Mice
Models, Animal
Obstetrics and Gynecology
Sex Ratio
Statistics as Topic
South America
Brazil
America
Human
Vertebrata
Mammalia
Mouse
Fertility
Animal
Rodentia
Female
Male
Air pollution
Ratio
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Summary:A significant negative association ( R2 = 0.7642; P =.013) between particulate matter and secondary sex ratio was found when evaluating people in the city of São Paulo, Brazil. An animal model with male mice raised in nonfiltered open-top chambers showed a significant reduction in the secondary sex ratio ( P =.041), suggesting that ambient air pollution may interfere with sex distribution by altering the X:Y sperm proportion in pollution-exposed males.
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2006.06.023