Respiratory failure during induction chemotherapy for acute myelomonocytic leukaemia (FAB M4Eo) with Ara‐C and all‐trans retinoic acid

We report two cases of acute myeloid leukaemia FAB classification M4Eo with high white cell counts at presentation, who developed acute respiratory failure with pulmonary infiltrates on chest radiograph soon after commencing conventional cytotoxic chemotherapy plus all‐trans retinoic acid (ATRA). We...

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Bibliographic Details
Published inBritish journal of haematology Vol. 109; no. 4; pp. 847 - 850
Main Authors Lester, W. A., Hull, D. R., Fegan, C. D., Morris, T. C. M.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Science Ltd 01.06.2000
Blackwell
Blackwell Publishing Ltd
Subjects
acute myelomonocytic leukaemia
Adult
all‐trans retinoic acid (ATRA)
AML 12
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Cytarabine - administration & dosage
Daunorubicin - administration & dosage
Dexamethasone - therapeutic use
Drug toxicity and drugs side effects treatment
Female
Glucocorticoids - therapeutic use
Hematology
Humans
induction therapy
Leukemia, Myelomonocytic, Acute - complications
Leukemia, Myelomonocytic, Acute - drug therapy
Medical sciences
Pharmacology. Drug treatments
Remission Induction
respiratory failure
Respiratory Insufficiency - drug therapy
Respiratory Insufficiency - etiology
Thioguanine - administration & dosage
Toxicity: respiratory system, ent, stomatology
Tretinoin - therapeutic use
Human
Antineoplastic agent
Drug combination
Respiratory disease
Toxicity
Retinoid
Malignant hemopathy
Induction treatment
Case study
Chemotherapy
Myelomonoblastic leukemia
Cytarabine
Antimetabolic
Respiratory failure
Adult
Complication
Female
Retinoic acid syndrome
Pyrimidine nucleoside
Retinoic acid
Tretinoin
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Summary:We report two cases of acute myeloid leukaemia FAB classification M4Eo with high white cell counts at presentation, who developed acute respiratory failure with pulmonary infiltrates on chest radiograph soon after commencing conventional cytotoxic chemotherapy plus all‐trans retinoic acid (ATRA). We suggest that in patients with M4Eo ATRA should be used with caution, perhaps delaying its commencement until the white cell count is < 10 x 109/l.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2000.02043.x