WASP and WIP regulate podosomes in migrating leukocytes
Podosomes are specialized adhesion sites found in rapidly migrating and invasive cells, most notably in cells from the myeloid lineage that participate in immune surveillance and phagocyte defence mechanisms. In this review, we describe the nature of leukocyte podosomes and the regulation of their t...
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Published in | Journal of microscopy (Oxford) Vol. 231; no. 3; pp. 494 - 505 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.09.2008
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Abstract | Podosomes are specialized adhesion sites found in rapidly migrating and invasive cells, most notably in cells from the myeloid lineage that participate in immune surveillance and phagocyte defence mechanisms. In this review, we describe the nature of leukocyte podosomes and the regulation of their turnover during migration by the key regulatory molecules Wiskott-Aldrich syndrome protein and WASP-interacting protein. |
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AbstractList | Summary
Podosomes are specialized adhesion sites found in rapidly migrating and invasive cells, most notably in cells from the myeloid lineage that participate in immune surveillance and phagocyte defence mechanisms. In this review, we describe the nature of leukocyte podosomes and the regulation of their turnover during migration by the key regulatory molecules Wiskott–Aldrich syndrome protein and WASP‐interacting protein. Podosomes are specialized adhesion sites found in rapidly migrating and invasive cells, most notably in cells from the myeloid lineage that participate in immune surveillance and phagocyte defence mechanisms. In this review, we describe the nature of leukocyte podosomes and the regulation of their turnover during migration by the key regulatory molecules Wiskott-Aldrich syndrome protein and WASP-interacting protein. |
Author | ANTÓN, I.M THRASHER, A.J JONES, G.E CALLE, Y |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18755005$$D View this record in MEDLINE/PubMed |
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Snippet | Podosomes are specialized adhesion sites found in rapidly migrating and invasive cells, most notably in cells from the myeloid lineage that participate in... Summary Podosomes are specialized adhesion sites found in rapidly migrating and invasive cells, most notably in cells from the myeloid lineage that participate... |
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SubjectTerms | Calpain cell adhesion cell migration Cell Movement Cytoskeletal Proteins - metabolism cytoskeleton Intracellular Signaling Peptides and Proteins - metabolism leukocytes Leukocytes - diagnostic imaging Leukocytes - physiology Models, Biological Ultrasonography WASP WIP Wiskott-Aldrich Syndrome Protein - metabolism |
Title | WASP and WIP regulate podosomes in migrating leukocytes |
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