WASP and WIP regulate podosomes in migrating leukocytes

Podosomes are specialized adhesion sites found in rapidly migrating and invasive cells, most notably in cells from the myeloid lineage that participate in immune surveillance and phagocyte defence mechanisms. In this review, we describe the nature of leukocyte podosomes and the regulation of their t...

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Bibliographic Details
Published inJournal of microscopy (Oxford) Vol. 231; no. 3; pp. 494 - 505
Main Authors CALLE, Y, ANTÓN, I.M, THRASHER, A.J, JONES, G.E
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.09.2008
Subjects
Calpain
cell adhesion
cell migration
Cell Movement
Cytoskeletal Proteins - metabolism
cytoskeleton
Intracellular Signaling Peptides and Proteins - metabolism
leukocytes
Leukocytes - diagnostic imaging
Leukocytes - physiology
Models, Biological
Ultrasonography
WASP
WIP
Wiskott-Aldrich Syndrome Protein - metabolism
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Summary:Podosomes are specialized adhesion sites found in rapidly migrating and invasive cells, most notably in cells from the myeloid lineage that participate in immune surveillance and phagocyte defence mechanisms. In this review, we describe the nature of leukocyte podosomes and the regulation of their turnover during migration by the key regulatory molecules Wiskott-Aldrich syndrome protein and WASP-interacting protein.
Bibliography:http://dx.doi.org/10.1111/j.1365-2818.2008.02062.x
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ISSN:0022-2720
1365-2818
DOI:10.1111/j.1365-2818.2008.02062.x